Submission ID 94008
| Poster Code | HR-P-17 |
|---|---|
| Title of Abstract | Tracking epilepsy-related gray matter atrophy across the lifespan: an ENIGMA study |
| Abstract Submission | Rationale. Magnetic resonance imaging (MRI) analysis can measure brain atrophy in temporal lobe epilepsy (TLE) and idiopathic generalized epilepsy (IGE)1. Research has mainly focused on linear effects of aging2,3. We capitalized on categorical and age-window analytics to probe the association between ageing and brain atrophy in the common epilepsies4. Methods. Participants. As part of ENIGMA-Epilepsy, we analyzed T1w MRI data in 885 healthy individuals (378 male; mean±SD age: 36.0±11.7 years), 769 TLE (314 males; mean±SD: 38.2±11.1 years; 430 left-sided focus) and 113 IGE patients (39 males; mean±SD 31.5±9.7 years). Young and old differences. Participants were divided into young and old cohorts via median age (35 years). Cortical thickness (CT; measured across 68 brain regions) and subcortical volume (SV; measured across 12 subcortical regions and bilateral hippocampi and ventricles) in TLE and IGE patients were compared to controls across both cohorts, while controlling for site, age, and sex and corrected at a false discovery rate (FDR) of p<0.05. Sliding age-window analysis. Using a window range of ± 2 years from the age of interest, the mean values for CT and SV regions were calculated for each age. These mean values were then multiplied by normally distributed weights to yield a weighted average for each brain region. This was repeated for every age of interest sliding across from 19-71 years of age for TLE patients, and 19-55 years of age for IGE patients. Results. The sliding age-window analysis revealed an accelerated decline with aging for TLE patients across cortical and subcortical regions (Fig 1A) and a steady decline for IGE patients (Fig 1B). Older TLE patients showed greater reductions in frontal and parietal cortical volumes and contralateral hippocampal atrophy than controls (Fig 2A). In contrast, differences between younger TLE patients and controls were limited only to the ipsilateral hippocampus, thalamus, and bilateral parietal regions. The older |
| Please indicate who nominated you | Dr. Aimee K Ryan, McGill University |
| What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? | Neurosciences, Mental Health and Addiction |
| What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? | Biomedical |
| PDF of abstract | ICAM_2023_abstract.pdf 2023-03-02 at 19:35:30 |
| Presenter and Author(s) | Judy Chen Judy Chen Alexander Ngo Sara LaRiviere Raul Rodriguez-Cruces ENIGMA Epilepsy Boris Bernhardt |
