Submission ID 93763

Poster Code HR-P-5
Title of Abstract How the brain processes fearful memories during sleep
Abstract Submission Sleep is essential for memory consolidation. Consistent with this role, sleep promotes communication between the structure where memories are initially formed (the hippocampus) and the structure where they are stored long-term (neocortex). This interregional communication happens through precise synchronized activity between the two structures that occurs during neuronal oscillations such as hippocampal sharp-wave ripples (SPW-Rs, 100-300 Hz) and cortical slow oscillations (1-4 Hz). The ventral midline thalamus (VMT) extends bidirectional connections to the medial prefrontal cortex (mPFC) and hippocampus, giving it an ideal anatomical position for organizing hippocampo-prefrontal coupling. Using closed-loop optogenetic stimulation and in vivo intracellular recording in mice, here we show that phasic inhibition of the VMT during hippocampal SWRs promotes the consolidation of fear memory during NREM sleep. In vivo intracellular recordings demonstrate that hippocampal SWRs inhibit the VMT and trigger thalamic bursting and prefrontal activation during slow oscillations. The result describe an inhibition-driven thalamic mechanism that organizes the transfer of hippocampal events to the thalamocortical system and promotes the long-term retention of memory.
Please indicate who nominated you Faculté de médecine, Université Laval
What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? Neurosciences, Mental Health and Addiction
What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? Biomedical
PDF of abstract No file
Presenter and Author(s) Diellor Basha
Diellor Basha
Igor Timofeev

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