Submission ID 93759
| Poster Code | HR-P-36 |
|---|---|
| Title of Abstract | A discriminative functional network profile of response to subcallosal cingulate deep brain stimulation for depression |
| Abstract Submission | Background: Subcallosal cingulate deep brain stimulation (SCC-DBS) is being investigated for treatment-resistant depression. However, the mechanisms underlying the modulatory effects of SCC-DBS are poorly understood, limiting its current therapeutic efficacy. Identifying functional biomarkers in SCC-DBS responders could inform the selection of DBS settings and improve response to SCC-DBS in non-responders. Methods: Magnetoencephalography data were obtained from 15 patients with SCC-DBS for treatment-resistant depression (seven responders) and 25 healthy subjects. Region-specific differences in neural oscillations were investigated using linear mixed models to identify discriminative nodes based on (i) differences in patients (responders and non-responders, stimulation-OFF) compared to healthy subjects, wherein (ii) activity was counteracted by stimulation in a responder-specific manner. Results: Oscillatory power analyses revealed differences in patients with depression compared to healthy subjects. SCC-DBS reversed these changes in responders via increased alpha (8-12 Hz) and decreased gamma (32-116 Hz) activity within nodes of the default mode, central executive, and somatomotor networks. Conclusions: SCC-DBS modulates oscillatory activity in brain regions involved in emotional control/processing, motor control, and the interaction between speech, vision, and memory, all of which have been implicated in depression. This modulated network profile in responders may represent a functional surrogate that can be used for DBS therapy optimization. |
| Please indicate who nominated you | Dr. Nicola Jones, MD/PhD Program Director, University of Toronto Kendra Hawke, MD/PhD Program Coordinator, University of Toronto |
| What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? | Neurosciences, Mental Health and Addiction |
| What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? | Clinical |
| PDF of abstract | ICAM_abstract_TRD_DBS_MEG.pdf 2023-02-17 at 13:09:30 |
| Presenter and Author(s) | Irene Harmsen Maximilian Scherer Nardin Samuel Gavin Elias Jurgen Germann Alexandre Boutet Peter Giacobbe Nathan Rowland Andres Lozano Luka Milosevic |
