Submission ID 93759

Poster Code HR-P-36
Title of Abstract A discriminative functional network profile of response to subcallosal cingulate deep brain stimulation for depression
Abstract Submission Background: Subcallosal cingulate deep brain stimulation (SCC-DBS) is being investigated for treatment-resistant depression. However, the mechanisms underlying the modulatory effects of SCC-DBS are poorly understood, limiting its current therapeutic efficacy. Identifying functional biomarkers in SCC-DBS responders could inform the selection of DBS settings and improve response to SCC-DBS in non-responders. Methods: Magnetoencephalography data were obtained from 15 patients with SCC-DBS for treatment-resistant depression (seven responders) and 25 healthy subjects. Region-specific differences in neural oscillations were investigated using linear mixed models to identify discriminative nodes based on (i) differences in patients (responders and non-responders, stimulation-OFF) compared to healthy subjects, wherein (ii) activity was counteracted by stimulation in a responder-specific manner. Results: Oscillatory power analyses revealed differences in patients with depression compared to healthy subjects. SCC-DBS reversed these changes in responders via increased alpha (8-12 Hz) and decreased gamma (32-116 Hz) activity within nodes of the default mode, central executive, and somatomotor networks. Conclusions: SCC-DBS modulates oscillatory activity in brain regions involved in emotional control/processing, motor control, and the interaction between speech, vision, and memory, all of which have been implicated in depression. This modulated network profile in responders may represent a functional surrogate that can be used for DBS therapy optimization.
Please indicate who nominated you Dr. Nicola Jones, MD/PhD Program Director, University of Toronto Kendra Hawke, MD/PhD Program Coordinator, University of Toronto
What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? Neurosciences, Mental Health and Addiction
What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? Clinical
PDF of abstract ICAM_abstract_TRD_DBS_MEG.pdf
2023-02-17 at 13:09:30
Presenter and Author(s) Irene Harmsen
Maximilian Scherer
Nardin Samuel
Gavin Elias
Jurgen Germann
Alexandre Boutet
Peter Giacobbe
Nathan Rowland
Andres Lozano
Luka Milosevic

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