Submission ID 93621
| Poster Code | HR-P-12 |
|---|---|
| Title of Abstract | Age-specific and gender-specific reference intervals for non-fasting lipids in French-Canadian children |
| Abstract Submission | Background: Dyslipidemias, including familial hypercholesterolemia (FH), are a risk factor for cardiovascular diseases (CVD). FH is a genetic disorder that affects cholesterol metabolism, leading to high levels of low-density lipoprotein cholesterol (LDL-C) and early cardiovascular disorders. The most common form of FH is heterozygous familial hypercholesterolemia (HeFH). This condition has a higher prevalence in French-Canadian population due to a founder effect. Even if the major complications of CDV occur in adulthood, atherosclerosis can begin in childhood. The latter is a critical period to screen for dyslipidemia. To do that, it is essential to have reference values adapted to the target population. Aim: The purpose of this study is to establish reference values for lipids in non-fasting state in healthy French-Canadian children, specific to gender and age, and considering the stage of puberty. Methods: Non-fasting blood samples were obtained from 386 children included in the GESTE cohort in Sherbrooke, Quebec. Lipid profiles, containing total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), non-HDL cholesterol (non-HDL-C) and apolipoprotein B (ApoB), were measured. Age- and gender-specific reference values and percentile curves were estimated with the GAMLSS method in the software RStudio. Results: Reference curves and 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles values were determined thanks to 356 samples of healthy non-obese children (n=204 aged 6-7 years and n=152 aged 9-13 years). 82 children were present at both follow-ups. As expected, significant difference was obtained for HDL-C (p<0,05) between girls and boys. Higher levels of TC (p<0,0001), HDL-C (p<0,0001) and TG (p<0.05) were observed in boys, in prepubertal stage as compared to puberty. Conclusions: Here, we reported for the first-time reference values for the French-Canadian children that could lead to a better diagnosis of dyslipidemia, and a better prevention against CVD. |
| Please indicate who nominated you | Artuela Çaku and Larissa Takser |
| What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? | Nutrition, Metabolism and Diabetes |
| What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? | Biomedical |
| PDF of abstract | ICAM_abstract_SophieBouhour.pdf 2023-02-16 at 13:59:35 |
| Presenter and Author(s) | Sophie Bouhour Virginie Gillet Artuela Çaku Rosalie Plantefève Larissa Takser |
