Submission ID 93085

Poster Code HR-P-18
Title of Abstract Efficacy of Microbial Ecosystem Therapeutic-2 (MET-2) on Symptoms of Major Depressive Disorder
Abstract Submission Background: Detailed analyses of the human gut microbiota have shown considerable individual variability in bacterial content as this system is influenced by a variety of factors, such as genetics, diet, metabolism, age, geography, antibiotic treatment, and stress. This dynamic system goes on to shape brain physiology and therefore behaviour through bidrectional gut-brain axis communication. Related research looking into the effects of gut microbiota on various neuropsychiatric disorders in animals and humans suggests that gut repopulation techniques may aid in improving depression symptoms and severity given the link between gut microbiota and central nervous system circuity development. Methods: Twenty-nine adult participants between 18-45 currently in a major depressive episode were recruited and orally consumed once daily a microbiome ecosystem therapeutic (MET-2) containing 40 strains of bacteria purified from a single healthy donor stool for a duration of 6 weeks. Participants completed a series of clinical assessments measuring symptom of mood, anxiety, and related symptoms in the form of validated clinical scales to assess clinical effects of the therapeutic. Findings: In a 12-patient pilot study, MET-2 was efficacious, generally safe, and tolerable, with limited side effects, and no serious adverse events. Seven of twelve individuals responded to treatment (50% improvement in MADRS/GAD-7 scores since starting treatment). Similarly, in the Phase 2 trial, of 29 patients included in this study, we notice majority patients' mood (n= 25) and anxiety (n=26) symptoms to improve over the course of the study. Upon unblinding, detailed analyses will be complete to determine placebo effect among these patients. This will be reported on the poster. Conclusions: The findings of this study will be the first to provide evidence for the role of microbial ecosystem therapy in treating depression in comparison to a placebo alternative.
Please indicate who nominated you Queen's University Faculty of Health Sciences and Centre for Neuroscience Studies - Dr. Tayade
What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? Neurosciences, Mental Health and Addiction
Nutrition, Metabolism and Diabetes
What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? Clinical
PDF of abstract No file
Presenter and Author(s) Arthi Chinna Meyyappan
Arthi Chinna Meyyappan
Cassandra Sgarbossa
Hayley Bromley
Roumen Milev
Daniel Mueller

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