Submission ID 92626
| Poster Code | HR-P-67 |
|---|---|
| Title of Abstract | Post-PASC Vaccination is associated with reduced clinical symptoms and inflammation in patients with Long COVID |
| Abstract Submission | Vaccination is associated with reduced clinical symptoms and inflammation in patients with Long COVID Maryam Nayyerabadi, Swarali Joshi, Prabha Chandrasekaran, Arpita Chakravarti, Chantal Massé, Marie-Lorna Paul, Joanie Houle, Amina Boubekeur, Charlotte Dusablon, Valérie Boudreau, Danijela Bovan, Emma Darbinian, Sandra Vinci, Pierre- Olivier Hétu, Johanne Poudrier, Emilia L. Falcone WHO defined PASC (Post-Acute Sequela of COVID-19) as the presence of symptoms 3 months after acute infection that lasts for more than 2 months. Vaccination against COVID-19 was launched to decrease the prevalence and severity of acute infections, but its effect on PASC is unclear. We investigated if vaccination against COVID-19 influences PASC clinical presentation and immune profile. In IPCO (the Institut de Recherches cliniques de Montréal (IRCM) Post-COVID-19 Research Clinic) we enrolled 83 participants at any time between 1 to 12 months from the date of COVID-19 diagnosis with follow-up visits scheduled at 3, 6, and 12 months; and 2 to 4 weeks after vaccination date. IPCO protocol includes collecting demographic characteristics and clinical at the baseline visit, and well-being score, clinical evaluation, review of vaccination status and adverse effects, 49 PASC symptoms evaluation, and blood sampling for CBC, CRP, fibrinogen, ferritin, D-dimer, cytokine and chemokine profile at each visit. The majority of participants were female (66.2%), with mild acute COVID-19 presentation (86.8%). Vaccinated participants had significantly fewer PASC symptoms, fewer organ systems affected, higher well-being score, and lower levels of cytokines/chemokines compared to the non-vaccinated group. We further observed correlations between certain cytokines/chemokines, as well as correlations between clinical parameters and certain cytokines/chemokines. Together, the data from this study demonstrate higher pro-inflammatory responses associated with PASC symptoms and identify the role of vaccination in mitigation. The protective role of vaccination likely goes beyond acute COVID-19 and extends to alleviate PASC, potentially by regulating the immune responses. |
| Please indicate who nominated you | Dr. Emilia Liana Falcone |
| What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? | Infection and Immunity |
| What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? | Biomedical |
| PDF of abstract | NayyerabadiMaryam.Abstract.pdf 2023-01-31 at 13:27:46 |
| Presenter and Author(s) | Maryam Nayyerabadi Emilia Falcone |
