Submission ID 91690
| Poster Code | HR-P-31 |
|---|---|
| Title of Abstract | Intracranial Pressure Based and Near Infrared Spectroscopy Based Indices of Cerebrovascular Reactivity are Associated in Higher Dimensional Physiologic Space for Moderate to Severe TBI Patients |
| Abstract Submission | Background: Disrupted cerebrovascular reactivity has been identified as an important contributor to secondary injury following moderate to severe traumatic brain injury (TBI). "Gold-standard" intracranial pressure (ICP) based indies of cerebrovascular reactivity are limited by their invasive nature poor spatial resolution. Near infrared spectroscopy (NIRS) based indices of cerebrovascular reactivity are a potential alternative as they are minimally invasive and have improved spatial resolution. In this study, classical machine-learning algorithms are leveraged to better characterize the relationship between these indices. Methods: High-resolution physiologic data was collected in a cohort of adult moderate to severe TBI patients. From this data both ICP and NIRS based indices of cerebrovascular reactivity were derived. Utilizing Agglomerative Hierarchical Clustering (AHC) and Principal Component Analysis, the relationship between these indices in higher dimensional physiologic space was examined. Results: A total of 83 patients with 314,395 minutes of unique and complete physiologic data was obtained. Through AHC and PCA there was higher order clustering between NIRS and ICP based indices, separate from other physiologic parameters. Conclusions: NIRS and ICP based indices of cerebrovascular reactivity relate to one another in higher dimensional physiologic space. NIRS based indices of cerebrovascular reactivity may be a viable alternative to ICP based indices. |
| Please indicate who nominated you | Dr. Shayne Taback Director, Clinician Investigator Program Max Rady College of Medicine University of Manitoba Email: Shayne.Taback@umanitoba.ca |
| What Canadian Institutes of Health Research (CIHR) institute is your research most closely aligned? | Neurosciences, Mental Health and Addiction |
| What Canadian Institutes of Health Research (CIHR) pillar of health research does your research fall under? | Biomedical |
| PDF of abstract | No file |
| Presenter and Author(s) | Alwyn Gomez Alwyn Gomez Amanjyot Singh Sainbhi Logan Froese Nuray Vakitbilir Kevin Stein Frederick A. Zeiler |
