Submission ID 118438
| Issue/Objective | Dengue causes an estimated 390 million infections annually, with South and Southeast Asian populations among those facing the highest burden of disease. Dengue is endemic in Bangladesh and recent years have brought cases to historic scales, including 316,484 cases in 2023. Increased dengue incidence in Bangladesh is compounded by densely populated urban centers, limited actions being taken for vector control, and climate change and concurring crises. Most cases occur in the capital, Dhaka, but without widespread testing, mild cases may go undetected or be mistaken for another illness. Dengue seroprevalence data in Dhaka is lacking, with most studies collecting data among small sample sizes or using low-sensitivity methods, such as rapid tests intended for diagnosis of acute infection. As part of a cluster randomized controlled trial (cRCT) in Dhaka, we are estimating seroprevalence of prior dengue infection among children 2-12 years old in February-May 2025. |
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| Methodology/Approach | We will recruit 5,848 children (and currently have recruited 3,090) to participate in this study. Data includes questionnaires administered to participating households, including information on prior dengue episodes, sociodemographics, environmental information, social capital, and dengue knowledge, attitudes, and practices (KAP). In each household, 1-2 children ages 2-12 years is tested for dengue IgG antibodies using a finger prick blood sampling method to collect dried blood spot samples for ELISA testing. We will estimate unadjusted dengue seroprevalence using logistic regression and inverse probability weighting, as well as examining associations of seroprevalence with age group, and households' socio-economic status, social capital, and KAP. |
| Results | Questionnaire and dengue IgG data will be analyzed descriptively after baseline data collection (May 2025), with preliminary results anticipated by July 2025. |
| Discussion/Conclusion | As part of a multi-year dengue serosurvey, this study will provide insight into the current dengue seroprevalence in a highly endemic setting with limited access to testing. |
| Presenters and affiliations | Laura Pierce Centre de recherche en santé publique, Université de Montréal Sakib Rahman BRAC James P Grant School of Public Health at BRAC University Anamul Hasan Infectious Diseases Division, icddr,b Mollah Moh. Shamsul Kabir Centre of Excellence for Science of Implementation and Scale-up , BRAC James P Grant School of Public Health, BRAC University Mohammad Sharif Hossain Infectious Diseases Division, icddr,b Adrien Saucier Centre de recherche en santé publique, Université de Montréal Jony Barnard BRAC James P Grant School of Public Health at BRAC University Mohammad Shafiul Alam Enteric and Respiratory Infections, Infectious Diseases Division, icddr,b Malay Kanti Mridha Center for Non-communicable Diseases and Nutrition, BRAC James P Grant School of Public Health at BRAC University Valéry Ridde Université Paris Cité, Paris, France Université Paris Cité, IRD, Inserm, Université Sorbonne Paris Nord Kate Zinszer University of Montreal School of Public Health, Centre de recherche en santé publique, Université de Montréal |
