| Issue/Objective |
This systematic review
and meta-analysis aimed to estimate the pooled prevalence of PTLD and determinants of Post-tuberculosis lung diseases
in sub-Saharan African countries |
| Methodology/Approach |
This study followed PRISMA guidelines for systematic review and meta-analysis. We
included studies reporting the prevalence and risk factors of PTLD among individuals with a
history of pulmonary TB in sub-Saharan Africa. A comprehensive literature search was conducted
in PubMed, Embase, Google Scholar and African Journals Online databases. The pooled
prevalence of PTLD was estimated using a random-effects model, and associated factors were analyzed using adjusted odds ratios (OR). |
| Results |
A total of 20 studies, comprising 3,968 participants, met the inclusion criteria. The overall
pooled prevalence of PTLD in sub-Saharan Africa was 40.57% (95% CI: 33.29%-47.86%).
Significant risk factors for PTLD include female sex (OR: 3.26, 95% CI: 2.10-5.07), smoking
(OR: 2.72, 95% CI: 1.30-5.70), and being underweight (OR: 2.35, 95% CI: 1.11-4.97). |
| Discussion/Conclusion |
Post-tuberculosis lung disease is a common complication among individuals with a
history of pulmonary TB in sub-Saharan Africa. To effectively manage post-tuberculosis lung
disease (PTLD) in sub-Saharan Africa, it is important to implement targeted interventions for high-
risk groups, strengthen screening and chronic care services, enhance healthcare system capacity,
and integrate PTLD management into national TB control programs |
| Presenters and affiliations |
Abraham Gebremedhn Armauer Hansen research institute |
